New Theory on Link Between Vitamin D and Cognitive Disorders

Australian researchers have a new theory explaining why vitamin D is so important to brain plasticity, and it involves perineuronal nets.

Vitamin D / Image: Nutritional Outlook
Vitamin D / Image: Nutritional Outlook

Over a billion people worldwide suffer a vitamin D deficiency, which is linked to cognitive disorders like schizophrenia and depression. A recent article from The University of Queensland says researchers have shown that vitamin D levels affect the structure of ‘scaffolding’ in the brain called perineuronal nets (PNNs), consisting of proteins and sugar molecules. “If you were going to get a net and throw it around a bean bag, the perineuronal net is the net, and the bean bag is a brain cell,” explains one researcher.

In the study, the team removed vitamin D from the diet of a group of healthy mice, while administering vitamin D to a control group. After 20 weeks, the vitamin deficient group showed a “significant decline” in their ability to remember and learn. When the brains of the vitamin D deficient mice were examined, the researchers noticed a reduction in PNNs and neuron connections in the hippocampus, the part of the brain in charge of forming memories. They believe vitamin D prevents certain enzymes from breaking down PNNs, which lead to cognitive disorders.

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