New Tool: ProSource
Checkout our packaging and processing solutions finder, ProSource.
Start Your Search

Tablet Press Solution

The Syntegon automatically adjustable powder feeder and Automated Process Development (APD) software allow pharmaceutical manufacturers to determine the ideal process parameters for each product.

Syntegon Adjustable Powder Feeder And Apd Software

Designed for use with tablet presses, the Syntegon automatically adjustable powder feeder and APD software offer pharmaceutical manufacturers a complete package to determine the ideal process parameters for each product and easily transfer them to production machines.

“While manual analyses used to take days or even weeks, the APD tool achieves faster and more precise results with much less product,” says Matthias Moessinger, senior market expert Pharma Solid at Syntegon. “Tablets have a significantly higher number of relevant parameters and quality attributes compared to capsules—from shape or diameter to thickness and hardness, numerous properties play an important role.”

The new powder feeding system is specifically tailored to the TPR 200 tablet press from Syntegon. The system can be adjusted automatically to fit every possible stirrer configuration. The impellers have a square and a round side to reflect factors such as the influence of powder movement on tablet properties. In addition, the speed and direction of rotation, as well as the inclination of the stirrer blades, can be varied.

During product tests, the APD software evaluates and optimizes the process parameters regarding their influence on critical quality attributes. As a major highlight, both the changeover of the feeding system and the tests are fully automated; human intervention is no longer necessary. The APD tool is based on Design of Experiments (DoE) and analyzes the functional relations between material properties, process parameters, and critical quality characteristics of the final product. This enables pharmaceutical manufacturers to accurately simulate the production situation and determine reliable parameters thanks to a clearly defined data basis. They save time, reduce product loss, increase product quality, and facilitate process validation.

The APD tool is suited for tests in the development phase, as well as for optimizing existing processes. Together with customers, Syntegon tests both active ingredients and placebo formulations at the OSD Customer Center in Waiblingen with the automated feeding system. “Our experts know the challenges and can support pharmaceutical manufacturers in determining the optimum process parameters based on decades of experience,” says Moessinger. “We have been technology leader in capsule processing for many years. Now our APD tool and automated powder feeding system also offer customers a structured and particularly efficient solution for process optimizations in tablet pressing. Further innovations will follow.”


Fill out the form below to request more information about Tablet Press Solution
Test Your Supply Chain Smarts
Take Healthcare Packaging's supply chain quiz to prove your knowledge!
Take Quiz
Test Your Supply Chain Smarts
Discover Our Content Hub
Access Healthcare Packaging's free educational content library!
Unlock Learning Here
Discover Our Content Hub