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TechnoPharm 2013 Bosch presents highlights from processing, inspection and isolator technology equipment for solid and liquid pharmaceuticals

• Tablets: mixing, granulating, pressing and coating on a laboratory scale • Compact inspection unit KKX 3900 for capsules • Fast Air Lock ISS 100: quick transfer into and out of isolators

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At TechnoPharm 2013 in Nuremberg, Germany (hall 6, booth 235), Bosch Packaging Technology presents highlights from its comprehensive pharmaceutical portfolio. The laboratory devices Solidlab 1 and 2, the Manesty tablet press Xpress 100, and the smallest high-shear mixer granulator Hüttlin Mycromix represent the process technology section. Novelties in inspection technology include the KKX 3900 inspection unit for filled capsules and the table-top device ETAC Easy View for visual inspection of containers filled with liquid pharmaceuticals. Bosch’s trade show appearance is rounded out by the Fast Air Lock ISS 1000 for quick transfer of pharmaceutical equipment into and out of isolators.

Laboratory devices for small batches
Since 2011, the product brands Hüttlin and Manesty are part of Bosch Packaging Technology’s portfolio. The two process technology specialists have jointly developed the laboratory machines Solidlab 1 and 2 for the manufacture of tablets and pellets. By using a common base assembly, the three process modules powder mixing, granulating and coating are combined in one single machine, enabling cost and space optimization. Solidlab 1 handles batches from 0.05 to two kilograms. Based on the same construction principle, Solidlab 2 processes volumes from 0.5 to 12 kilograms.

Hüttlin Mycromix is the smallest high-shear mixer granulator in the laboratory equipment range. It handles batches from 0.05 to one kilogram. The bottom drive unit Hüttlin Gentlewing ensures highly homogenous mixing qualities for granulates. All processes can be easily transferred to production equipment via scale-up. The tablet press Manesty Xpress 100 is equally suited for research and development purposes. Its data acquisition system provides an ideal platform for evaluation of new tableting formulations. With a range of flexible turret options, clinical trial batches can also be produced. On the Xpress 100 the same mpower-software is used as on production machines, enabling easier comparison of test results.

Pioneers in inspection and isolator technology
The inspection unit KKX 3900 is used for weight and quality control of filled hard capsules. It can be installed after any capsule filling machine and achieves an output of up to 220,000 capsules per hour. The system is based on soft x-ray technology and inspects quality parameters such as weight and length of capsules with high accuracy. Apart from the 100 percent inline weight control, the digital image evaluation gathers further process-relevant information.

The inspection technology portfolio from Eisai Machinery includes manual, semi- and fully-automated systems. The computer-bound visual inspection unit ETAC Easy View, for instance, examines vials, ampoules, syringes and cartridges for particle contamination and cosmetic container defects and is designed for containers with diameters from 8 to 50 millimetres. A camera transmits the results directly to the All-in-One computer, which allows for an especially fast evaluation. Due to its compact design, the user-independent and fully validatable table-top device is flexibly applicable.

The Fast Air Lock ISS 1000 was developed for transferring pharmaceutical equipment into and out of isolators. An efficient evaporation process and an optimized loading unit result in very fast cycle times of only approximately 20 minutes. The ISS 1000 is available as integrated or stand alone module and operates independently from the main filling isolator.

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