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Kindeva Drug Delivery Invests in Second Manufacturing Line for Greener Inhalers

Drug-device manufacturer Kindeva invests in additional production capacity at U.K. manufacturing site for next-generation inhalers with minimal environmental impact.

Kindeva

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Kindeva Drug Delivery, a global provider of drug-device combination products, announced its investment in a second manufacturing line for the production of pressurized metered-dose inhaler (pMDI) products containing low-GWP (Global Warming Potential) propellants in its Loughborough, U.K., facility.

This new line will be capable of handling both HFA-152a and HFO-1234ze propellants—that have a GWP of 90% and 99.9% lower than the industry standard HFA-134a, respectively—and is anticipated to be operational in 2026. Kindeva’s first pMDI manufacturing line, which was announced in 2022, is in its installation phase and will be completed later in 2024.

Milton Boyer, Kindeva’s CEO, said, “This investment will bring to the market one of the first large-volume commercial green propellant lines to the contract manufacturing market capable of supplying up to 50 million pMDI units per year. This second investment in low-GWP GMP manufacturing capacity further underscores Kindeva’s commitment to enable the pharmaceutical industry to meet its sustainability goals, whilst ensuring patient choice is not compromised. With our first GMP low-GWP manufacturing line expected to be operational in 2024, we are proud to be leading the transition to low-GWP propellants by ensuring the capacity is available.”

The new manufacturing line meets an increased customer demand for more sustainable pMDI products and considers the recent adoption of F-gas legislation in the European Union. Phase down of the existing propellants will commence in 2027 in the EU and be completed by the end of 2029.

Boyer continued: “With a track record of nearly 70 years in pMDIs— ncluding the invention of the pMDI in 1956 and leading the CFC- to HFA-inhaler transition in the 1990s—we are excited to be a part of this industry-wide switch in the pMDI space. Kindeva is doing everything we can to ensure a greener future for all stakeholders by doubling down on our commitment to the low-GWP evolution.”

This announcement marks a continuation in the next chapter of Kindeva’s leadership in driving sustainable innovation in pMDIs and, more broadly, complex drug and combination products.

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