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Gene Therapy Aims to Relieve Chronic Pain

Scientists at NYU have developed a pioneering gene therapy targeting chronic pain by modulating the activity of specific sodium ion channels on neurons.

Nyu
NYU

According to a recent Medgadget article, researchers at NYU have made significant strides in the field of gene therapy by creating a novel approach to alleviate chronic pain. The team focused on a critical component of pain perception – the NaV1.7 sodium ion channel found on neurons. With genetic engineering, they encoded a specialized peptide that facilitates the binding of a modulatory protein known as CRMP2 to the NaV1.7 channel. This engineered change disrupted CRMP2's normal interaction with the sodium channel, resulting in decreased pain transmission.

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