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Examining transdermal delivery developments

Meeting the demands for transdermal delivery of cosmeceuticals, nutraceuticals, and aromatherapy requires converter assistance.

Fabrico shows a sample of die-cut materials for cosmeceutical applications.
Fabrico shows a sample of die-cut materials for cosmeceutical applications.

The market for cosmeceuticals, nutraceuticals, and aromatherapy is rapidly expanding as the ability to deliver these items using transdermal patches is further refined. From patches for anti-aging products to essential oils for homeopathic remedies to vitamins and nutrients for soldiers in the battlefield, transdermal patch technology has blossomed since the introduction of the first nicotine patches decades ago.

Worldwide cosmeceutical sales alone, according to a research report from RNCOS, an information and analysis company, describes a market worth $27.2 billion in 2010, with expected growth to $38.4 billion (9% Compound Annual Growth Rate) by 2014.

The evolution of transdermal delivery

At the time of their introduction, transdermal drug delivery systems generated tremendous excitement over their potential for:
• Avoidance of immediate elimination of a drug by the liver
• Avoidance of the gastrointestinal tract
• Improved patient compliance
• Controlled delivery of drugs with short half-lives

However, it soon became clear there were drawbacks:
• Skin irritation from a “patch”
• Limits on dosage
• Lag time while the drug was delivered through the skin
• Variation in absorption rate based on skin type, patient age, etc.
• Limits on the kinds of drugs that could be absorbed through the skin

Candidate drugs for transdermal delivery were pretty much limited to nitroglycerin, scopolamine, clonidine, estrogen, testosterone, nicotine, and fentanyl. The skin turns out to be a rather formidable barrier with poor penetration by most compounds with large molecular weights, like proteins and peptides. Drugs with high lipid solubility pass easily, but drugs with low lipid solubility need a membrane carrier or active transport system.

New developments for increasing skin penetration include solid dispersions, microemulsions, self-emulsifying systems, complexation, liposomes, and nanostructured particles using molecular modeling. Along with changes in transdermal drug delivery technology came an increasing use of transdermals in over–the-counter applications.

Cosmeceuticals, nutraceuticals, and aromatherapy

While drug delivery development languished, transdermal delivery became more popular in areas where design and manufacturing complexity and regulatory monitoring were less intense: cosmeceuticals, nutraceuticals, and aromatherapy.

Cosmeceuticals

What are cosmeceuticals? The definition has been blurred over the years and confused, since any company can call almost any cosmetic product a cosmeceutical. Most often, a cosmeceutical delivers some active ingredients through the skin, while cosmetics are more “topical” in nature. Some industry experts would like to define them as products that don’t require a prescription, but are only available from professionals such as doctors, aestheticians, healthcare professionals, and technicians.

Today’s most popular cosmeceuticals include:
• Teeth whiteners
• Lip protection
• Skincare, especially anti-aging products
• Haircare
• Scarless wound healing, or anti-scarring treatments

Nutraceuticals

Nutraceuticals can include everything from nutritional supplements to complete emergency nutritional delivery systems for those without access to meals for a period of time, for example soldiers in the field, firefighters, miners, and astronauts.

Dietary and nutritional supplements benefit from transdermal delivery:
• Instant and continuous delivery to the bloodstream
• Time-release delivery
• Delivery of the optimal dosage strength
• No breakdown in the harsh, acidic digestive system
• Convenient dosage

Aromatherapy

Aromatherapy has become increasingly popular for:
• Relaxation and stress relief
• Increased circulation to warm muscles
• Mood enhancements

LAST CHANCE TO SAVE! New Tech for Life Sciences at PACK EXPO Southeast
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LAST CHANCE TO SAVE! New Tech for Life Sciences at PACK EXPO Southeast