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Romaco: Macofar Micromaxx 24 Microdosing Machine

Microdosing machine for sterile powders and liquids.

Macofar MicroMaxX 24 microdosing machine.
Macofar MicroMaxX 24 microdosing machine.

Romaco Group,  a supplier of processing and packaging equipment, launches its Macofar MicroMaxX 24 aseptic powder filling machine. The supplier will also show selected tableting and processing technologies from Kilian and Innojet.

The Macofar MicroMaxX 24 microdosing machine is designed with intermittent motion and to an output of up to 24,000 vials an hour. This technology is mainly to be used to fill injectable aseptic powders. The MicroMaxX 24 is built to be equipped with a dual powder dosing disc which should allow multiple dosing into the same vial; alternatively, the product could be filled in two separate process steps. The vacuum/pressure system of the machine is made to process a wide range of pharmaceutical powders with different flow properties. Even very small product quantities, such as 20 mg, can be dosed precisely, according to the company. Furthermore, the MicroMaxX 24 has a filling station meant for sterile liquids. 

An innovative in-line weighing system should offer improved weight control even at the machine’s full filling speed of 24,000 vials per hour. Measurements are carried out at two stations before and after filling the vials, and then they are closed in a sterile way with rubber stoppers. Romaco Macofar’s MicroMaxX 24 can be configured with open RABS depending on the customer’s requirements. The linear transport principle which was chosen for the vials and the slimmer design of the automated system together are meant to enable a more reliable filling process. The use of servo technology should also ensure a low-turbulence environment in the production area. The MicroMaxX 24 is meant to comply with cGMP requirements for dosing sterile powders into vials. 

Romaco Innojet Ventilus V 5 processing machine

The laboratory-scale version of the Romaco Innojet Ventilus V 5 is used for granulating, drying, and coating particle sizes from 10 µm to 2 mm. The Ventilus V 5 is designed to allow up to 25% shorter batch times. The homogeneous flow conditions inside the cylindrical product container are meant to enable extremely gentle intermixing of the batch. The process air is controlled by the Orbiter booster, a container bottom consisting of overlapping circular plates. Together with the Rotojet—the central bottom spray nozzle—the Orbiter booster forms an innovative functional unit that should meet all the requirements for linear scale-ups. The air flow bed technology is meant to ensure accurate control of the product movement and equally precise application of the spray liquids. The resulting formulations could therefore achieve the required release profile with between 10 and 15% less spray liquid. 

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