Novel Drug Reverses Alzheimer’s In Mice

The cellular cleaning process is called chaperone-mediated autophagy (CMA), and it identifies unwanted proteins in the body and digests and recycles them. The researchers tested the drug that promotes CMA on mice that had been genetically engineered to have brain neurons that lacked CMA, causing Alzheimer’s-like symptoms like impaired walking and short-term memory loss. After treatment, the mice showed improvements in memory, depression and anxiety, and improved walking ability with reduced tau protein levels and protein clumps.