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Innovative delivery systems: Rise in chronic conditions calls for new packaging to ensure home compliance

As therapies target specialized disease areas, at-home delivery of these therapies designed with patients in mind will help to ensure compliance while offering pharmaceutical manufacturers the opportunity to differentiate their products.

West SmartDose
West SmartDose

According to a 2011 report on non-communicable disease by the United Nations, chronic conditions such as heart disease, cancer, diabetes, auto-immune, and lung disease are responsible for 63% of all deaths worldwide (36 million out 57 million global deaths).1

In the U.S., the Center for Disease Control and Prevention notes that more than 133 million Americans—or 45% of the population—suffer from at least one chronic condition, while 26% have multiple conditions. In fact, chronic conditions account for nearly 75% of U.S. health care costs.2

Therapies are in place to treat these conditions and, to help control costs, at-home and self-injection delivery methods are on the rise. Thanks to the increase in monoclonal antibody and other biologic drug therapies, many of these conditions can be treated with self-injection therapies that are tailored specifically to the disease.

Home healthcare innovations

Recent and incipient innovations in therapies for cholesterol, asthma, oncology, and other conditions have made in-home treatment possible, helping to remove the high cost and compliance issues associated with clinical therapy. Therapies for conditions including rheumatoid arthritis have evolved to include delivery systems that enable self-injection by the patient or a caregiver in any setting. Syringe-based auto-injectors and cartridge-based pens that facilitate self-injection have been marketed for several years, and the evolution continues through new technologies that enable more patient-friendly administration of life-changing therapies.

For example, Cimzia® (certolizumab injection) from UCB has an OXO Good Grips® wide-grip finger-flange and needle shield removal system designed for those with dexterity issues. In the area of oncology, Roche/Genentech aims to bring Herceptin® (trastuzumab injection) and other drug products to the home market using the Mydose® single-dose infusion device, which allows delivery of high-volume drugs to patients.

Design for adherence and ease of use

The drive for high-quality packaging has helped manufacturers focus on increasing consistency of performance in devices such as auto-injector and patch injection systems. In addition, there is an increased focus on providing drug delivery systems that are easy to use.

To create a specialized, patient-centric system that is truly user-friendly while ensuring consistency, human factors testing and delivery specifications must be employed. A consistent quality of components can help to improve performance and ensure delivery in the home environment, where the success of the system is crucial to patient compliance.

In many current delivery systems, the device is reliant on a purely mechanical power source to inject the drug dosage. Should this mechanism fail to perform properly, the patient may receive an incomplete dose, particularly in systems where there is no way for the patient to manipulate the device. In such cases, the patient may get a sub-therapeutic dose and may not maintain compliance with the prescribed therapy. The failure may also cause a potential recall for the drug manufacturer, which can be costly not only financially, but also in terms of patient preference and brand loyalty.

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