Patch Analyzes Sweat to Monitor, Diagnose Health Issues

Epifluidics technology could be deployed in clinical settings or in the home to monitor patients remotely. Could its materials present new flexible packaging opportunities?

Epifluidics technology could be deployed in clinical settings or in the home to monitor patients remotely.
Epifluidics technology could be deployed in clinical settings or in the home to monitor patients remotely.

Consumers and medical professionals are no stranger to wearable patches, employing them to monitor exercise regimens, track vital signs, blood pressure, glucose levels and other health information.

As long ago as the 1960s, relates Packaging Hall of Fame inductee Ben Miyares, we’ve had transdermal patches, one of which he recalls, functioned like a “contact lens,” releasing eye medication in a controlled fashion.

An intriguing new patch type is currently in development at the intersection of advanced materials and device innovation that employs Epifluidics (epidermal + microfluidics) technology. It is described in a Jan. 18 New York Times article as “A new device—wearable, wireless and battery-free—[that] improves the ability to monitor and diagnose health problems by analyzing the sweat on your skin.

“The new device has minuscule holes at its base into which sweat naturally flows. From there, a complex network of valves and microchannels, each roughly the width of a human hair, route the sweat into tiny reservoirs. Each reservoir contains a sensor that reacts with a chemical in the sweat, such as glucose or lactate,” the story explains.

The “key architect of the device,” said the NYT story: Prof. John Rogers, Biomedical Engineer at Northwestern University. Rogers told the NYT, “It fits into a broader trend that you’re seeing in medicine, which is personalized, tailored approaches to treatment and delivery of care.”

To learn more about the “sweat patch,” we followed up with Rogers’ co-author of the research article, Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat, describing the technology, Roozbeh Ghaffari, PhD. Ghaffari is CEO/Co-Founder of Epicore Biosystems, a spin-off of the Northwestern lab, tasked with pursuing commercialization of the sweat microfluidics technology.

Healthcare Packaging (HCP): How will this patch be used?

Ghaffari: Our research paper showcased “Electronics-Enabled Epifluidics” devices, highlighting the integration of electrochemical sensors onboard epifluidic devices. Epifluidic devices have important medical applications. We anticipate this technology being deployed in clinical settings and at home to monitor patients remotely. On the commercialization front, we have initially focused on consumer wellness and beauty and sports applications, with the goal to expand into more regulated applications with medical claims in the future.

HCP: Is the patch is being evaluated for its potential to identify or address several different diseases/conditions?

Yes, we have active studies with clinical collaborators in progress where we are testing epifluidic devices in stroke rehabilitation, cystic fibrosis screening and kidney disease screening, to name a few.

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