New Study May Have Identified Cause of Alzheimer’s

To test this, the team used two mouse models: a genetically modified group with livers that produce the protein-fat complex that is suspected to cause Alzheimer’s, and an unmodified control group. Both groups were subjected to a fear-motivated memory test for cognitive functions. They then harvested tissue samples from the mice including liver, brain, lung, and duodenum. They found that the dysfunction in the blood-brain barrier led to the protein-fat complexes leaking from the blood into the brain, where it caused inflammation. The team found that a marker of neurodegeneration was roughly two times greater in the test mice than in the control group.