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Oxygen absorption takes many forms, packages

Oxygen absorber from Mitsubishi extends shelf life and can be incorporated into sheet, bottles, blisters and film layers.

Oxygen absorber from Mitsubishi extends shelf life and can be incorporated into sheet, bottles, blisters and film layers.
Oxygen absorber from Mitsubishi extends shelf life and can be incorporated into sheet, bottles, blisters and film layers.

From being stuck inside a truck or plane in hot weather during drug distribution, to warm summer days on the kitchen or bathroom shelf in the consumer’s home, packaged pharmaceuticals are under attack. Oxygen and moisture are the enemies, and the collective efforts of materials scientists and the packaging are mounting the defense.

Three trends boost the need for effective oxygen absorption solutions, both active and passive:

• Drug manufacturers want increased shelf life for their formulations, to optimize costs in manufacturing and distribution.

• The U.S. Food and Drug Administration (FDA) wants longer shelf life, with full potency, for the drugs they regulate.

• A higher proportion of molecules in the drug pipeline are in Classes II and IV. These classes of molecules are often formulated in such a way as to make them more sensitive to oxygen.

The Healthcare Compliance Packaging Council’s recent study, "Prescription Packaging In-Use Stability Study, " pointed out possible adverse effects daily exposure to moisture and oxygen can have on non-coated tablets stored in traditional amber pharmacy vials, plastic bottles and low-barrier blister films—right in consumer’s homes.

The study tested these packaging formats along with PVC/PVDC and Aclar® blisters under normal usage conditions, higher humidity levels and higher temperatures, and found that significant physical changes can occur in tablets when distributed in low barrier or multi-use containers in as little as 30 days.

Innovative Oxygen Absorption Packaging Solutions,” was the title of an informative Innovation Stage presentation at Pharma EXPO 2015 from Atsushi Inoue, R&D Manager at Mitsubishi Gas Chemical Company.

Researched List: Blister Machines for Life Sciences
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Researched List: Blister Machines for Life Sciences
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Break out of the ordinary: see what’s new in life sciences packaging