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U.K. school of pharmacy, tool maker team up for tableting

Project aims to address anti-stick research for tablets to address processing problems and determine the best tableting characteristics.

Hp 20191 I Stock Tablets 000016019271 X Small
An April 3 report from in-pharmatechnologist.com reports that U.K.-based tooling maker IHolland "has teamed up with researchers at the University of Nottingham's School of Pharmacy on TSAR-Tabletting Science Anti-stick Research-a two-year project that aims to develop a way of predicting which formulations have the best tableting characteristics."

Nottingham's School of Pharmacy Web site notes, "Our school leads the U.K. in the training of future pharmacists and in undertaking world-changing research.

Schiff Nutrition, a Salt Lake City, UT, maker of vitamins, nutritional supplements, and sports nutrition products recently solved an occasional problem where its multimineral tablets were sticking in the dies of a rotary tablet press and needed to alleviate that challenge, and improve tablet hardness to better withstand packaging and shipping. In this instance, Schiff employed software from Stat-Ease to design an experiment that revealed that using double-sided presses would virtually eliminate its difficulties.

A scribd.com article, "Problems during tablet manufacturing," said formulation and equipment can lead to tablet compression process problems that include sticking, double printing, weight variation, and hardness. Some of those problems "are not detected during the development of a particular tablet formulation, only appearing during scale -up as the processing speed is increased. Some of the problems experienced during tableting can be solved by shifting the formulation or alleviated by altering the tableting conditions. It is the early detection and accurate diagnosis of any of these flaws that can avoid tablet compression process failure and consequently improve its reliability, safety, reduce process downtime and the overall operating cost."
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