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Sanofi Aventis boosts processing, packaging efficiency

Plants in Cologne, Germany, and Lisieux, France install granulation systems that include filling, weighing, and wash-in-place systems.

Hp 19563 Sanofi Huttlin Mixer Granulator
Sanofi-Aventis is a global pharmaceutical company, headquartered in Bridgewater, NJ. Among its products is Doliprane®, a brand of Acetaminophen tablets, a medication used in most of Europe for pain and fever reduction.

Through its Hüttlin division, the Oystar USA Process and Packaging Technology Div. is supporting Sanofi Aventis' Doliprane process. In Cologne, Germany, Oystar Hüttlin HTG 1800 and HD 600 units produced granulates for a total of 359 million effervescent tablets for the French market in 2009.

That production was made possible through the installation of a fully integrated granulating line. No manual operations of any kind are necessary from dust-free loading via bags to container filling. The HTG 1800 high-shear mixer granulator and the HD 600 fluidized bed system are equipped with pneumatic filling mechanisms, including integrated weighing, pneumatic empty mechanisms, as well as pneumatic transfer between the mixer and fluidized bed, providing a closed production process.

In Lisieux, France, Sanofi Aventis had the automated HDGC 1200 fluidized bed granulation system from OYSTAR Hüttlin installed with an upstream bag unloading station. The apparatus carries out two process steps: spray granulation and the drying process in a single product container. The initial output makes the production of granulates possible for more than 500 million Acetaminophen tablets per year. As at Cologne, an efficient cleaning concept is provided to prevent cross-contamination. Each plant is automatically cleaned and dried overnight via a wash-in-place (WIP) system from the loading station to discharge, so that products can be manufactured the following morning with the highest degree of purity.
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